CLK2 inhibitor Indazole1

CAS No. ——

CLK2 inhibitor Indazole1( Indazole1 )

Catalog No. M16934 CAS No. ——

CLK2 inhibitor Indazole1 is a novel potent, selective inhibitor of CLK2 with IC50 of 2.7 nM.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    CLK2 inhibitor Indazole1
  • Note
    Research use only, not for human use.
  • Brief Description
    CLK2 inhibitor Indazole1 is a novel potent, selective inhibitor of CLK2 with IC50 of 2.7 nM.
  • Description
    CLK2 inhibitor Indazole1 is a novel potent, selective inhibitor of CLK2 with IC50 of 2.7 nM, 60-fold selectivity over PKA and >600-fold selectivity over a panel of 34 kinases; rescues spine density in mouse brain slices at 300 nM; displays 96-fold more potent than TG003 in the CLK2 Caliper assay.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Indazole1
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    CLK
  • Recptor
    CLK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    ——
  • Formula Weight
    324.428
  • Molecular Formula
    C19H24N4O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    (S)-4-methyl-1-((5-(3-methyl-1H-indazol-5-yl)pyridin-3-yl)oxy)pentan-2-amine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lerchner AM, et al. ChemMedChem. 2018 Jul 9. doi: 10.1002/cmdc.201800344.
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